|
KMID : 0363320110320020170
|
|
Journal of Korean Oriental Internal Medicine
2011 Volume.32 No. 2 p.170 ~ p.187
|
|
|
Effect of Yagwan-cheunghyeoltang on Obesity in Rats Induced by High Fat Diet
|
|
Park Sang-Woo
Cho Chung-Sik
Kim Chul-Jung
|
|
|
Abstract
|
|
|
Background: Obesity, the syndrome caused by a high fat diet, is a disease. At the same time, obesity causes diabetes mellitus, hyperlipidemia, and cardiovascular disease. Recently, its prevalence rate is increasing. Yagwan-cheunghyeoltang (YCT) used in this experiment is the prescription of Yagwanmoon added to Cheunghyeol-tang which is reported to be very effective in weight loss controlling and serum cholesterol. It is also reported that Yagwanmoon has significant antioxidant effects and YCT has a significant effect on blood glucose control.
Objectives: This study was conducted to experimentally evaluate the effects of YCT on obesity in rats induced by high fat diet.
Methods: The experiment was conducted with 4-week-old male rat s divided into 5 groups. They were a normal diet group, a high fat diet group, a positive drug control group, a 1% YCT group, and a YCT 3% group, and were tested for eight weeks. After four weeks of inducing obesity by a high fat diet, rats were allowed to lose weight by following the normal diet group, approximately 30% compared with 10 rats in each group were determined as still obese. Changes in body weight and organ weight and serum cholesterol, triglyceride, glucose-density, low density lipoprotein cholesterol, antioxidant activity were checked.
Results: In the experimental groups, we observed weight loss and visceral fat reduction, improvement of liver function, reduction of serum glucose, activation of HMG-CoA reductase inhibitor, reduction of concentrations of leptin and it showed a significant effect on antioxidants and lipid peroxidation.
Conclusions : YCT has significant effects on the regulation of hyperlipidemia and lipid peroxidation associated with obesity and has significant effects on, antioxidants and lipid peroxidation, too. Additional clinical studies are needed.
|
|
|
KEYWORD
|
|
|
obesity, Yagwan-cheunghyeoltang, high fat diets
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|